Sasaki Hiroki, Abe Osamu, Yamasue Hidenori, Fukuda Rin, Yamada Haruyasu, Takei Kunio, Suga Motomu, Takao Hidemasa, Kasai Kiyoto, Aoki Shigeki, Ohtomo Kuni
Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Neuroimage. 2009 Jun;46(2):505-10. doi: 10.1016/j.neuroimage.2009.02.007. Epub 2009 Feb 20.
Chronic excessive alcohol intake results in alcohol-related brain damage. Many previous reports have documented alcohol-related global or local brain shrinkage or diffusional abnormalities among alcoholics and heavy to moderate drinkers; however, the influence of relatively low levels of alcohol consumption on brain structural or diffusional abnormality is unclear. We investigated structural or diffusional abnormalities related to lifetime alcohol consumption (LAC) using voxel-based morphometry (VBM) among Japanese non-alcohol-dependent individuals (114 males, 97 females). High-resolution three-dimensional magnetic resonance images and diffusion tensor imaging were acquired in all subjects. The collected images were normalized, segmented, and smoothed using SPM 5. Gray matter volume (GMV) and white matter volume (WMV) were normalized for each total intracranial volume (TIV), and partial correlation coefficients were estimated between normalized GMV or WMV and lifetime alcohol consumption (LAC) adjusted for age. To investigate regional GMV or WMV abnormalities related to LAC, multiple regression analyses were performed among regional GMV or WMV and LAC, age, and TIV. To investigate subtle regional abnormalities, multiple regression analyses were performed among fractional anisotropy (FA) or mean diffusivity (MD), and LAC and age. No LAC-related global or regional GMV or WMV abnormality or LAC-related regional FA abnormality was found among male or female subjects. Significant LAC-related MD increase was found in the right amygdala among female subjects only. The current results suggest female brain vulnerability to alcohol, and a relation between subtle abnormality in the right amygdala and alcohol misuse.
长期过量饮酒会导致酒精相关的脑损伤。此前许多报告都记录了酗酒者以及重度至中度饮酒者中与酒精相关的全脑或局部脑萎缩或扩散异常情况；然而，相对低水平的酒精摄入对脑结构或扩散异常的影响尚不清楚。我们在日本非酒精依赖个体（114名男性，97名女性）中使用基于体素的形态测量法（VBM）研究了与终生饮酒量（LAC）相关的结构或扩散异常。所有受试者均采集了高分辨率三维磁共振图像和扩散张量成像。收集的图像使用SPM 5进行归一化、分割和平滑处理。灰质体积（GMV）和白质体积（WMV）针对每个总颅内体积（TIV）进行归一化，并估计归一化后的GMV或WMV与经年龄调整的终生饮酒量（LAC）之间的偏相关系数。为了研究与LAC相关的区域GMV或WMV异常，对区域GMV或WMV与LAC、年龄和TIV进行了多元回归分析。为了研究细微的区域异常，对分数各向异性（FA）或平均扩散率（MD）与LAC和年龄进行了多元回归分析。在男性或女性受试者中均未发现与LAC相关的全脑或区域GMV或WMV异常或与LAC相关的区域FA异常。仅在女性受试者的右侧杏仁核中发现了与LAC相关的MD显著增加。目前的结果表明女性大脑对酒精更易受损，以及右侧杏仁核的细微异常与酒精滥用之间存在关联。
