Jang Dong-Pyo, Namkoong Kee, Kim Jae-Jin, Park Sangjin, Kim In-Young, Kim Sun I, Kim Young-Bo, Cho Zang-Hee, Lee Eun
Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon, Korea.
Neurosci Lett. 2007 Nov 20;428(1):21-6. doi: 10.1016/j.neulet.2007.09.047. Epub 2007 Sep 29.
The aim of this study was to explore local brain atrophy of patients with alcohol dependence using a voxel-based analysis of magnetic resonance images and to investigate the relationship of those atrophic regions with drinking history and neuropsychological performances. Statistical parametric mapping was applied for the global and regional comparison of segmented gray matter and white matter images from 20 patients with alcohol dependence and with those from 20 controls. The Rey auditory-verbal learning test, Rey-Osterrieth complex figure test, Stroop test, trail-making test, and Wisconsin card sorting test were conducted as neuropsychological evaluations. There was a significant decrease in both gray matter and white matter globally in alcohol dependence. Bilateral parahippocampal white matter areas were reduced in particular. Perseverative responses and perseverative errors in the Wisconsin card sorting test had significant correlation with the decrease of gray matter decrease including the left superior temporal gyri and right postcentral region. The psychological performance measures correlated with gray matter rather than white matter, whereas right temporal white matter correlated with drinking amount for last 4 weeks. This may imply that alcohol consumption in heavy amounts damages both gray matter and white matter, and gray matter atrophy mainly leads to cognitive impairment, whereas white matter is related to drinking history.
本研究的目的是利用基于体素的磁共振图像分析来探索酒精依赖患者的局部脑萎缩情况，并研究这些萎缩区域与饮酒史及神经心理学表现之间的关系。应用统计参数映射对20例酒精依赖患者和20例对照者的分割灰质和白质图像进行整体和区域比较。进行了雷氏听觉词语学习测验、雷-奥斯特里茨复杂图形测验、斯特鲁普测验、连线测验和威斯康星卡片分类测验作为神经心理学评估。酒精依赖患者的灰质和白质在整体上均显著减少。双侧海马旁白质区域尤其减少。威斯康星卡片分类测验中的持续性反应和持续性错误与包括左侧颞上回和右侧中央后区域在内的灰质减少显著相关。心理表现测量指标与灰质而非白质相关，而右侧颞叶白质与过去4周的饮酒量相关。这可能意味着大量饮酒会损害灰质和白质，灰质萎缩主要导致认知障碍，而白质与饮酒史有关。
