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鸡α-珠蛋白基因结构域远上游片段中一个依赖转录的脱氧核糖核酸酶I高敏感位点与一个核基质附着区域重合。

A transcription-dependent DNase I-hypersensitive site in a far upstream segment of the chicken alpha-globin gene domain coincides with a matrix attachment region.

作者信息

de Moura Gallo C V, Vassetzky Y S, Huesca M, Scherrer K

机构信息

Institut Jacques Monod, Université Paris 7, France.

出版信息

Biochem Biophys Res Commun. 1992 May 15;184(3):1226-34. doi: 10.1016/s0006-291x(05)80013-0.

DOI:10.1016/s0006-291x(05)80013-0
PMID:1590785
Abstract

A site of hypersensitivity to DNase I has been found at the 5'-side of the chicken alpha-globin gene domain, ca. 8 Kbp upstream to the first gene. The presence of this site in different types of chicken cells correlates with the transcriptional status of the domain. A matrix attachment region (MAR) has also been found in the same subfragment, suggesting that it may be involved in the control of transcription of the chicken alpha-globin genes.

摘要

在鸡α-珠蛋白基因结构域的5'端，即第一个基因上游约8千碱基对处，发现了一个对DNase I敏感的位点。该位点在不同类型鸡细胞中的存在与该结构域的转录状态相关。在同一亚片段中还发现了一个基质附着区域（MAR），这表明它可能参与鸡α-珠蛋白基因转录的调控。

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A transcription-dependent DNase I-hypersensitive site in a far upstream segment of the chicken alpha-globin gene domain coincides with a matrix attachment region.鸡α-珠蛋白基因结构域远上游片段中一个依赖转录的脱氧核糖核酸酶I高敏感位点与一个核基质附着区域重合。
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