Faure E
E.R. Biodiversity and Environment, case 5, University of Provence, Place Victor Hugo, 13331 Marseilles cedex 3, France.
Med Hypotheses. 2005;65(3):509-20. doi: 10.1016/j.mehy.2005.02.044.
Reports of multiple sclerosis developing after hepatitis B vaccination have led to the concern that this vaccine might be a cause of multiple sclerosis in previously healthy subjects. Some articles evidenced that minor Hepatitis B virus (HBV) polymerase proteins could be produced by alternative transcriptional or translational strategies. Their detection is very difficult because they are in minute concentration and probably enzymatically inactive, however, it was shown that they could be exposed on the outside of the virus particles and also be immunogenic. In addition, HBV polymerase shares significant amino acid similarities with the human myelin basic protein. We hypothesise that some of the apparent adverse reactions to the vaccine could be due to a process called of molecular mimicry, the HBV polymerase, which could be a contaminant in the recombinant or plasma-derived vaccines, could act as autoantigens and induce autoimmune demyelinating diseases such as multiple sclerosis.
乙肝疫苗接种后发生多发性硬化症的报告引发了人们对该疫苗可能导致此前健康个体患多发性硬化症的担忧。一些文章证明，乙肝病毒（HBV）聚合酶的小分子蛋白可能通过替代转录或翻译策略产生。由于其浓度极低且可能无酶活性，因此很难检测到它们，然而，研究表明它们可能暴露在病毒颗粒表面并且具有免疫原性。此外，HBV聚合酶与人髓鞘碱性蛋白在氨基酸上有显著的相似性。我们推测，疫苗的一些明显不良反应可能是由于一种称为分子模拟的过程，HBV聚合酶可能是重组疫苗或血浆衍生疫苗中的污染物，它可以作为自身抗原并诱发自身免疫性脱髓鞘疾病，如多发性硬化症。
