Qian Yan, Fan Jian-Gao
Center for Fatty Liver Disease, First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China.
Hepatobiliary Pancreat Dis Int. 2005 May;4(2):173-7.
It has been suggested that obesity and fatty liver may be associated with the morbidity and mortality of liver cancer, and the early diagnosis and effective treatment of fatty liver coupled with liver cancer are supposed to improve the prognosis of obese patients. This review was attempted to understand the relationship between obesity, fatty liver and liver cancer.
An English-language literature search using PUBMED (1990-2004) on obesity, fatty liver and liver cancer and other related articles in Chinese.
Obesity is associated with the risk of death from all cancers and from cancers at individual sites including liver cancer, and it is an independent risk factor for hepatocellular carcinoma (HCC) in patients with alcoholic cirrhosis and cryptogenic cirrhosis. Because nonalcoholic steatohepatitis has been implicated as a major cause of cryptogenic cirrhosis, the development of HCC may be part of progressive nature of this condition.
Obesity is associated with the incidence and mortality of HCC. More frequent surveillance for HCC may be warranted in obese patients with fatty liver and attempts should be made to interrupt the progression from simple hepatic steatosis to steatohepatitis, cirrhosis and ultimately HCC.
有人提出肥胖和脂肪肝可能与肝癌的发病率和死亡率相关，对合并肝癌的脂肪肝进行早期诊断和有效治疗有望改善肥胖患者的预后。本综述旨在了解肥胖、脂肪肝与肝癌之间的关系。
利用PUBMED（1990 - 2004年）对肥胖、脂肪肝和肝癌进行英文文献检索，并检索中文相关文章。
肥胖与所有癌症以及包括肝癌在内的个别部位癌症的死亡风险相关，并且是酒精性肝硬化和隐源性肝硬化患者肝细胞癌（HCC）的独立危险因素。由于非酒精性脂肪性肝炎被认为是隐源性肝硬化的主要原因，HCC的发生可能是这种疾病进展的一部分。
肥胖与HCC的发病率和死亡率相关。对于肥胖合并脂肪肝的患者，可能有必要更频繁地监测HCC，并且应尝试中断从单纯肝脂肪变性到脂肪性肝炎、肝硬化并最终发展为HCC的进程。
