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伴放线放线杆菌AfeABCD不依赖铁载体的铁摄取系统的遗传与功能分析

Genetic and functional analyses of the Actinobacillus actinomycetemcomitans AfeABCD siderophore-independent iron acquisition system.

作者信息

Rhodes Eric R, Tomaras Andrew P, McGillivary Glen, Connerly Pamela L, Actis Luis A

机构信息

Department of Microbiology, Miami University, 40 Pearson Hall, Oxford, OH 45056, USA.

出版信息

Infect Immun. 2005 Jun;73(6):3758-63. doi: 10.1128/IAI.73.6.3758-3763.2005.

DOI:10.1128/IAI.73.6.3758-3763.2005
PMID:15908408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1111845/
Abstract

The Actinobacillus actinomycetemcomitans afeABCD iron transport system, the expression of which is controlled by iron and Fur, was identified in three different isolates. The protein products of this locus are related to bacterial ABC transporters involved in metal transport. Transformation of the Escherichia coli 1017 iron acquisition mutant with a plasmid harboring afeABCD promoted cell growth under iron-chelated conditions. However, insertion disruption of each of the afeABCD coding regions abolished this growth-relieving effect. The replacement of the parental afeA allele with the derivative afeA::EZ::TN drastically reduced the ability of A. actinomycetemcomitans cells to grow under iron-chelated conditions.

摘要

在三种不同的分离株中鉴定出了伴放线放线杆菌的afeABCD铁转运系统，其表达受铁和铁调节蛋白（Fur）的控制。该基因座的蛋白质产物与参与金属转运的细菌ABC转运蛋白有关。用携带afeABCD的质粒转化大肠杆菌1017铁摄取突变体可促进其在铁螯合条件下的细胞生长。然而，afeABCD每个编码区域的插入破坏都消除了这种促进生长的作用。用衍生物afeA::EZ::TN替代亲本afeA等位基因，极大地降低了伴放线放线杆菌细胞在铁螯合条件下生长的能力。

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Differences in iron acquisition from human haemoglobin among strains of Actinobacillus actinomycetemcomitans.伴放线放线杆菌菌株间从人血红蛋白获取铁的差异。
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