Prinz P N, Moe K E, Vitiello M V, Marks A L, Larsen L H
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle 98195.
J Geriatr Psychiatry Neurol. 1992 Apr-Jun;5(2):65-71. doi: 10.1177/002383099200500202.
Sleep-wake rhythms are known to be altered in Alzheimer's disease (AD) and in unipolar depression. Other evidence suggests that the circadian rhythm in body temperature may be altered as well. Entrained circadian temperature rhythms were measured in healthy elderly men and women, as well as in men and women suffering from unipolar depression or mild AD, to examine this possibility. There were no differences in the temperature rhythm characteristics of subjects with depression or AD compared with healthy control subjects. However, gender differences were observed. Female control subjects showed a larger amplitude, higher peak temperature, and earlier acrophase relative to male control subjects. Also, the mesor of female AD subjects was higher than for male AD subjects. These results are discussed in the context of the widely varying subject populations used in other studies.
众所周知，阿尔茨海默病（AD）和单相抑郁症患者的睡眠-觉醒节律会发生改变。其他证据表明，体温的昼夜节律也可能发生改变。为了探究这种可能性，对健康老年男性和女性以及患有单相抑郁症或轻度AD的男性和女性的昼夜体温节律进行了测量。与健康对照受试者相比，抑郁症或AD受试者的体温节律特征没有差异。然而，观察到了性别差异。与男性对照受试者相比，女性对照受试者的振幅更大、峰值温度更高且体温高峰相位更早。此外，女性AD受试者的均数比男性AD受试者的高。将在其他研究中使用的广泛不同的受试者群体的背景下讨论这些结果。
