RNA Bioinformatics/High Throughput Analysis, Faculty of Mathematics and Computer Science, Friedrich Schiller University Jena, 07743 Jena, Germany.
Matthias Schleiden Institute, Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, Germany.
Cells. 2020 Aug 8;9(8):1862. doi: 10.3390/cells9081862.
Understanding the process of aging is still an important challenge to enable healthy aging and to prevent age-related diseases. Most studies in age research investigate the decline in organ functionality and gene activity with age. The focus on decline can even be considered a paradigm in that field. However, there are certain aspects that remain surprisingly stable and keep the organism robust. Here, we present and discuss various properties of robust behavior during human and animal aging, including physiological and molecular biological features, such as the hematocrit, body temperature, immunity against infectious diseases and others. We examine, in the context of robustness, the different theories of how aging occurs. We regard the role of aging in the light of evolution.
了解衰老过程仍然是实现健康衰老和预防与年龄相关疾病的重要挑战。大多数衰老研究都在研究器官功能和基因活性随年龄的下降。对下降的关注甚至可以被认为是该领域的一个范例。然而，有些方面仍然惊人地稳定，使生物体保持强健。在这里，我们介绍和讨论了人类和动物衰老过程中稳健行为的各种特性，包括生理和分子生物学特征，如血细胞比容、体温、抗感染免疫力等。我们从稳健性的角度考察了衰老发生的不同理论。我们从进化的角度看待衰老的作用。
