Daimon K, Yamada N, Tsujimoto T, Takahashi S
Department of Psychiatry, Shiga University of Medical Science, Japan.
J Affect Disord. 1992 Nov;26(3):191-8. doi: 10.1016/0165-0327(92)90015-x.
We investigated circadian rhythms of body temperature in 62 inpatients with major depressive episodes, by monitoring the deep body temperature through the abdominal skin every two hours for a consecutive 48-h period. The data were analyzed by both the least-squares method and the maximum entropy spectral analysis (MEM) and were compared with those in 29 normal volunteers who apparently had a regular 24-h sleep-wake schedule. Circadian rhythm phase disturbances in the depressed patients were likely to be manifested in a phase normal or a phase delay pattern rather than in a phase advance pattern. The amplitude of body temperature was significantly smaller and the mesor was higher in the depressed patients than in the normal subjects. Analysis by MEM revealed that the periods of circadian rhythm of body temperature tended to be longer in the depressed patients than in the normal subjects, though there was no significant difference. The power spectral density by MEM was significantly lower, and there were significantly more ultradian rhythm components in the depressed patients than in the normal subjects. These findings suggest that the fundamental rhythm disturbance in depression may be a weakening of the coupling processes between internal pacemakers and an abnormal sensitivity to environmental information.
我们通过连续48小时每两小时监测一次腹部皮肤的深部体温，对62例重度抑郁发作的住院患者的体温昼夜节律进行了研究。数据采用最小二乘法和最大熵谱分析（MEM）进行分析，并与29名明显有规律的24小时睡眠-清醒时间表的正常志愿者的数据进行比较。抑郁患者的昼夜节律相位紊乱可能表现为相位正常或相位延迟模式，而非相位提前模式。抑郁患者的体温振幅明显较小，中值较高。MEM分析显示，抑郁患者的体温昼夜节律周期虽与正常受试者无显著差异，但有延长趋势。抑郁患者的MEM功率谱密度显著较低，超日节律成分显著多于正常受试者。这些发现表明，抑郁症的基本节律紊乱可能是内部起搏器之间耦合过程的减弱以及对环境信息的异常敏感性。
