[Glutathione metabolism in rat cardiac tissues in acute doxorubicin-induced intoxication].

Experimental data are presented on the influence of acute doxorubicin intoxication with 7.47 and 2.34 mg/kg body mass on glutathione metabolism in cardiac tissues of albino non-inbred rats. Doxorubicin toxic effect resulted in such marked changes as decreased concentration of reduced glutathione and abnormal levels of glutathione reductase, glucoso-6-phoshate dehydrogenase, glutathione peroxidase and glutathione-S-transferase. Possible causes of such biochemical changes as well as their role in causation of doxorubicin cytotoxic effect are discussed. New methods of prophylaxis and lab diagnosis of doxorubicin-induced cardiomyopathy are suggested.