Leary Sam, Ness Andy, Emmett Pauline, Davey Smith George
Unit of Paediatric and Perinatal Epidemiology, Department of Community-based Medicine, University of Bristol, 24 Tyndall Avenue, Bristol BS8 1TQ, UK.
J Epidemiol Community Health. 2005 Jun;59(6):467-72. doi: 10.1136/jech.2004.029884.
To examine the association between maternal diet in pregnancy and offspring height, sitting height, and leg length.
Cohort study.
South west England.
6663 singletons (51% male) enrolled in the Avon longitudinal study of parents and children, with information on their mother's diet in late pregnancy (obtained by food frequency questionnaire) and their own height recorded at age 7.5 years.
Before adjustment, maternal magnesium, iron, and vitamin C were the nutrients most consistently associated with offspring height and its components. However, adjusting for potential confounders weakened all relations considerably. For example, a standard deviation (SD) increase in magnesium intake was associated with a 0.10 (-0.07, 0.14) SD unit increase in height before adjustment, which was reduced to 0.05 (0.01, 0.08) SD units after adjustment, and a SD unit increase in iron intake was associated with 0.08 (0.05, 0.12) and 0.04 (0.01, 0.08) SD unit increases in height before and after adjustment respectively. No other dietary variables were associated with height or its components after adjustment.
These findings do not provide evidence that maternal diet in pregnancy has an important influence on offspring height, sitting height, or leg length in well nourished populations, although effects may emerge as offspring become older.
探讨孕期母亲饮食与后代身高、坐高和腿长之间的关联。
队列研究。
英格兰西南部。
6663名单胎婴儿（51%为男性）参与了埃文亲子纵向研究，有其母亲孕晚期饮食信息（通过食物频率问卷获得）以及他们7.5岁时的身高记录。
调整前，母亲摄入的镁、铁和维生素C是与后代身高及其组成部分最常相关的营养素。然而，对潜在混杂因素进行调整后，所有关联均大幅减弱。例如，镁摄入量增加一个标准差（SD），调整前与身高增加0.10（-0.07，0.14）SD单位相关，调整后降至0.05（0.01，0.08）SD单位；铁摄入量增加一个SD单位，调整前与身高增加0.08（0.05，0.12）SD单位相关，调整后与身高增加0.04（0.01，0.08）SD单位相关。调整后没有其他饮食变量与身高或其组成部分相关。
这些发现并未提供证据表明孕期母亲饮食对营养良好人群的后代身高、坐高或腿长有重要影响，尽管随着后代年龄增长可能会出现影响。
