重型β地中海贫血青春期女性的下丘脑-垂体-性腺功能

Hypothalamic-pituitary-gonadal function in adolescent females with beta-thalassemia major.

作者信息

Al-Rimawi H S, Jallad M F, Amarin Z O, Obeidat B R

机构信息

Department of Pediatrics, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

出版信息

Int J Gynaecol Obstet. 2005 Jul;90(1):44-7. doi: 10.1016/j.ijgo.2005.03.024.

DOI:10.1016/j.ijgo.2005.03.024

PMID:15913630

Abstract

OBJECTIVE

To evaluate the function of the hypothalamic-pituitary-gonadal axis in adolescent female patients with beta-thalassemia major.

MATERIALS AND METHODS

A prospective study of the function of the hypothalamic-pituitary-gonadal axis function of 31 beta-thalassemia major females aged between 13 and 22 years and in 12 control females aged between 12 and 22 years. All were treated at Princess Rahma Teaching Hospital, Irbid, Northern Jordan between April 2001 and April 2003.

RESULTS

Of the 31 beta-thalassemia major females, 13 (41.9%) had delayed puberty. Hypothalamic-pituitary-ovarian axis dysfunction was found in 15 patients (48.4%). Twelve patients (38.7%) had hypogonadotropic hypogonadism and 5 (16.1%) had ovarian failure. High levels of serum ferritin were significantly higher in patients with delayed puberty.

CONCLUSION

Pituitary and ovarian dysfunction are common problems in beta-thalassemia major patients. The main possible cause is iron overload. This stresses the need for intensive and regular use of chelation therapy to prevent damage to the hypothalamic-pituitary-ovarian axis.

摘要