Hematology/Oncology Department, Children's Hospital and Research Center at Oakland, California, USA.
Ann N Y Acad Sci. 2010 Aug;1202:226-30. doi: 10.1111/j.1749-6632.2010.05583.x.
Preserving fertility, preventing early menopause, and predicting reproductive ability have become crucial for many adult thalassemia major females. Luteinizing hormone/follicle-stimulating hormone (LH/FSH) and estradiol, commonly used for assessment of fertility potential in thalassemia, have a poor predictive value. Current reproductive practice uses markers of ovarian reserve testing, which were not yet studied in thalassemia women. We explored the relationship between liver iron concentration (LIC) and fertility status in 26 females (mean 30 years old). Seventeen (65%) of them experienced primary or secondary amenorrhea. Levels of LH/FSH and estradiol were low or undetectable in 48% and 35% of patients, respectively and did not correlate with age, presence of amenorrhea, and LIC. This further addresses the need for utilization of current available methods for assessment of fertility capacity in thalassemia, which will also allow future correlation with pituitary iron measures by MRI as well as early intervention for fertility preservation.
对于许多成年地中海贫血症女性来说，保持生育能力、预防早期绝经和预测生育能力已变得至关重要。黄体生成素/卵泡刺激素 (LH/FSH) 和雌二醇常用于评估地中海贫血症的生育潜能，但预测价值不佳。目前的生殖实践使用卵巢储备测试标志物，但尚未在地中海贫血症女性中进行研究。我们研究了 26 名女性（平均 30 岁）的肝铁浓度 (LIC) 与生育状况之间的关系。其中 17 名（65%）经历原发性或继发性闭经。LH/FSH 和雌二醇水平分别在 48%和 35%的患者中较低或无法检测到，并且与年龄、闭经的存在以及 LIC 无关。这进一步说明了需要利用当前可用的方法来评估地中海贫血症的生育能力，这也将允许未来通过 MRI 与垂体铁测量值进行相关性分析，并进行早期生育保存干预。
