微生物的微型分子：细菌中的非编码调控RNA

Micros for microbes: non-coding regulatory RNAs in bacteria.

作者信息

Gottesman Susan

机构信息

Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA.

出版信息

Trends Genet. 2005 Jul;21(7):399-404. doi: 10.1016/j.tig.2005.05.008.

DOI:10.1016/j.tig.2005.05.008

PMID:15913835

Abstract

Small non-coding RNAs with important regulatory roles are not confined to eukaryotes. Recent studies have led to the identification of numerous small regulatory RNAs in Escherichia coli and in other bacteria. As in eukaryotic cells, a major class of these small RNAs acts by base-pairing with target mRNAs, resulting in changes in the translation and stability of the mRNA. Roles for these non-coding pairing RNAs in bacteria have been demonstrated in several cases. Because these non-coding RNAs act post-transcriptionally, they impose a regulatory step that is independent of and epistatic to any transcriptional signals for their target mRNAs.

摘要

具有重要调控作用的小非编码RNA并不局限于真核生物。最近的研究已在大肠杆菌和其他细菌中鉴定出许多小调控RNA。与真核细胞一样，这些小RNA中的一大类通过与靶标mRNA碱基配对发挥作用，从而导致mRNA的翻译和稳定性发生变化。在一些情况下已证明了这些非编码配对RNA在细菌中的作用。由于这些非编码RNA在转录后发挥作用，它们施加了一个独立于其靶标mRNA的任何转录信号且与之上位性的调控步骤。