大肠杆菌转运RNA与D-组氨酸和D-赖氨酸通过氨酰转运RNA合成酶的酯化反应。
Esterification of Escherichia coli tRNAs with D-histidine and D-lysine by aminoacyl-tRNA synthetases.
作者信息
Takayama Toshimitsu, Ogawa Tetsuhiro, Hidaka Makoto, Shimizu Yoshihiro, Ueda Takuya, Masaki Haruhiko
机构信息
Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
出版信息
Biosci Biotechnol Biochem. 2005 May;69(5):1040-1. doi: 10.1271/bbb.69.1040.
It is generally believed that only L-amino acids are acceptable in protein synthesis, though some D-amino acids, including D-tyrosine, D-aspartate, and D-tryptophan are known to be bound enzymatically to tRNAs. In this report, we newly show that D-histidine and D-lysine are also able to be the substrates of respective Escherichia coli aminoacyl-tRNA synthetases.
一般认为，在蛋白质合成中只有L-氨基酸是可接受的，尽管已知一些D-氨基酸，包括D-酪氨酸、D-天冬氨酸和D-色氨酸可通过酶促作用与tRNA结合。在本报告中，我们首次表明D-组氨酸和D-赖氨酸也能够分别作为大肠杆菌氨酰-tRNA合成酶的底物。
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