白内障手术患者房水中左氧氟沙星随时间的分布情况。
Levofloxacin disposition over time in aqueous humor of patients undergoing cataract surgery.
作者信息
Pea Federico, Ferrari Ettore, Pavan Federica, Roman-Pognuz Derri, Bandello Francesco, Furlanut Mario
机构信息
Institute of Clinical Pharmacology and Toxicology, DPMSC, University of Udine, P. le S. Maria della Misericordia 3, 33100 Udine, Italy.
出版信息
Antimicrob Agents Chemother. 2005 Jun;49(6):2554-7. doi: 10.1128/AAC.49.6.2554-2557.2005.
Abstract
The ocular disposition of levofloxacin in patients receiving two 500-mg oral doses 10 h apart before cataract surgery was assessed with the intent of defining drug ocular exposure over time. The mean aqueous humor concentrations persisted above 1.5 mg/liter between 1.5 and 6.0 h after the second dose, with average aqueous-to-plasma ratios ranging between 0.33 and 0.57. This favorable ocular disposition provides support for trials of systemic levofloxacin for prophylaxis of postoperative endophthalmitis in selected patients or as adjunctive therapy for the treatment of this potentially devastating infective complication.
摘要
为了确定随时间变化的药物眼部暴露情况，对白内障手术前10小时接受两次间隔500毫克口服剂量左氧氟沙星的患者进行了眼部处置评估。第二次给药后1.5至6.0小时，房水平均浓度持续高于1.5毫克/升，房水与血浆的平均比值在0.33至0.57之间。这种有利的眼部处置情况为在特定患者中使用全身性左氧氟沙星预防术后眼内炎或作为治疗这种潜在毁灭性感染性并发症的辅助疗法的试验提供了支持。
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