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灵长类动物脊柱关节病

Primate spondyloarthropathy.

作者信息

Rothschild Bruce M

机构信息

Arthritis Center of Northeast Ohio, 5500 Market Street, Youngstown, OH 44512, USA.

出版信息

Curr Rheumatol Rep. 2005 Jun;7(3):173-81. doi: 10.1007/s11926-996-0036-0.

Abstract

Spondyloarthropathy is a common occurrence in Old World primates, with only limited presence in New World monkeys. Clearly distinguished from rheumatoid arthritis, this erosive arthritis afflicts 20% of great apes, baboons, and rhesus macaques and had been increasing in frequency. Habitat-dependent infectious agent diarrhea-induced reactive arthritis is implicated on a background of genetic predisposition. A gorilla-derived therapeutic preventative approach has possible application in human clinical medicine.

摘要

脊柱关节病在旧世界灵长类动物中很常见,在新世界猴中则仅有少量存在。这种侵蚀性关节炎与类风湿性关节炎有明显区别,在20%的大猩猩、狒狒和恒河猴中出现,且发病率一直在上升。在遗传易感性背景下,与栖息地相关的感染性因子腹泻诱发的反应性关节炎受到牵连。一种源自大猩猩的治疗性预防方法可能应用于人类临床医学。

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