Kim Jeong Wook, Jeon Woo Kyu, Kim Eun Jeong
Department of Internal Medicine, Chungang University Yongsan Hospital, Chungang University College of Medicine, Seoul, Republic of Korea.
Clin Nutr. 2005 Oct;24(5):785-93. doi: 10.1016/j.clnu.2005.04.004.
The aim of this study was to examine whether the combined administration of bovine colostrum and glutamine was able to prevent the non-steroidal anti-inflammatory drug (NSAID)-induced gut damage and bacterial translocation (BT) in the rats.
The animal model population of the study consisted of six groups; control group, diclofenac group, diclofenac with milk group, diclofenac with colostrum group, diclofenac with glutamine group and diclofenac with colostrum and glutamine group. The animals with milk, colostrum or glutamine were fed with low fat milk, liquid colostrum or glutamine by orogastric gavage for 5 days before the diclofenac administration. Intestinal permeability, serum biochemical profiles and intestinal adhesion for assessment of the gut damage, and enteric bacterial overgrowth and BT at the mesenteric lymph nodes, liver, spleen and systemic blood were measured.
Diclofenac caused the increase in gut damage, enteric bacterial numbers and BT. Supplements with colostrum or glutamine reduced these changes induced by diclofenac, but this result was not seen for supplementation with low fat milk. Combined administration of colostrum and glutamine reduced diclofenac-induced gut damage and BT as compared to the use of bovine colostrum alone or glutamine alone.
This study suggested that the combined administration of bovine colostrum and glutamine might effectively reduce NSAID-induced gut damage and BT in the rat.
本研究旨在探讨联合给予牛初乳和谷氨酰胺是否能够预防大鼠非甾体抗炎药（NSAID）诱导的肠道损伤和细菌移位（BT）。
本研究的动物模型群体分为六组；对照组、双氯芬酸组、双氯芬酸加牛奶组、双氯芬酸加初乳组、双氯芬酸加谷氨酰胺组以及双氯芬酸加初乳和谷氨酰胺组。在给予双氯芬酸前5天，通过经口胃管饲法给饮用牛奶、初乳或谷氨酰胺的动物喂食低脂牛奶、液态初乳或谷氨酰胺。测量肠道通透性、血清生化指标以及肠道粘连情况以评估肠道损伤，并检测肠系膜淋巴结、肝脏、脾脏和全身血液中的肠道细菌过度生长和细菌移位情况。
双氯芬酸导致肠道损伤、肠道细菌数量和细菌移位增加。补充初乳或谷氨酰胺可减轻双氯芬酸诱导的这些变化，但补充低脂牛奶未出现此结果。与单独使用牛初乳或谷氨酰胺相比，联合给予初乳和谷氨酰胺可减轻双氯芬酸诱导的肠道损伤和细菌移位。
本研究表明，联合给予牛初乳和谷氨酰胺可能有效减轻大鼠非甾体抗炎药诱导的肠道损伤和细菌移位。
