Taylor Alison, Verhagen Johan, Akdis Cezmi A, Akdis Mübeccel
Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland.
Microbes Infect. 2005 Jun;7(7-8):1049-55. doi: 10.1016/j.micinf.2005.03.029. Epub 2005 Apr 25.
Anergy, tolerance and active suppression may not be independent events, but rather involve similar mechanisms and cell types in immune regulation. Induction of allergen-specific T(Reg) cells seems essential for maintaining a healthy immune response towards allergens. By utilizing multiple secreted cytokines and surface molecules, antigen-specific T(Reg) cells may re-direct an inappropriate immune response against allergens or auto-antigens.
无反应性、耐受性和主动抑制可能并非独立事件，而是在免疫调节中涉及相似的机制和细胞类型。诱导过敏原特异性调节性T细胞似乎对于维持针对过敏原的健康免疫反应至关重要。通过利用多种分泌的细胞因子和表面分子，抗原特异性调节性T细胞可能会重新引导针对过敏原或自身抗原的不适当免疫反应。
