使用可重构硬件加速ClustalW多序列比对。
Using reconfigurable hardware to accelerate multiple sequence alignment with ClustalW.
作者信息
Oliver Tim, Schmidt Bertil, Nathan Darran, Clemens Ralf, Maskell Douglas
机构信息
School of Computer Engineering, Nanyang Technological University, Singapore.
出版信息
Bioinformatics. 2005 Aug 15;21(16):3431-2. doi: 10.1093/bioinformatics/bti508. Epub 2005 May 26.
Abstract
Aligning hundreds of sequences using progressive alignment tools such as ClustalW requires several hours on state-of-the-art workstations. We present a new approach to compute multiple sequence alignments in far shorter time using reconfigurable hardware. This results in an implementation of ClustalW with significant runtime savings on a standard off-the-shelf FPGA.
摘要
使用诸如ClustalW之类的渐进比对工具比对数百个序列，在最先进的工作站上需要花费数小时。我们提出了一种新方法，可使用可重构硬件在短得多的时间内计算多序列比对。这使得在标准的现成FPGA上实现的ClustalW在运行时大幅节省时间。
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