Olesen Kristin M, Jessen Heather M, Auger Catherine J, Auger Anthony P
Department of Psychology, University of Wisconsin, Madison, 1202 West Johnson Street, Madison, Wisconsin 53706, USA.
Endocrinology. 2005 Sep;146(9):3705-12. doi: 10.1210/en.2005-0498. Epub 2005 May 26.
Steroid receptor activation in developing brain influences a variety of cellular processes that endure into adulthood, altering both behavior and physiology. We report that estrogen receptors can be activated in a ligand-independent manner within developing brain by membrane dopamine receptors. Neonatal treatment with either estradiol or a dopamine D1 receptor agonist can increase the expression of an estrogen receptor-regulated gene (i.e. progestin receptors) and later juvenile social play. More importantly, increases in social play behavior induced by neonatal treatment with estradiol or a dopamine D1 receptor agonist can be prevented by prior treatment with an estrogen receptor antagonist. This suggests that changes in dopamine transmission in developing brain can activate estrogen receptors in a ligand-independent manner to influence gene expression and have lasting consequences on social behavior.
发育中的大脑中类固醇受体的激活会影响多种持续到成年期的细胞过程，改变行为和生理机能。我们报告称，在发育中的大脑内，膜多巴胺受体可通过非配体依赖的方式激活雌激素受体。用雌二醇或多巴胺D1受体激动剂对新生动物进行治疗，可增加雌激素受体调控基因（即孕激素受体）的表达以及后期幼年动物的社交玩耍行为。更重要的是，用雌激素受体拮抗剂预先处理，可阻止新生动物接受雌二醇或多巴胺D1受体激动剂治疗后所诱导的社交玩耍行为增加。这表明，发育中大脑内多巴胺传递的变化可通过非配体依赖的方式激活雌激素受体，从而影响基因表达，并对社交行为产生持久影响。
