爱泼斯坦-巴尔病毒BZLF1蛋白与有丝分裂染色体结合。
Epstein-Barr virus BZLF1 protein binds to mitotic chromosomes.
作者信息
Adamson Amy L
机构信息
Department of Biology, University of North Carolina at Greensboro, Greensboro, NC 27402, USA.
出版信息
J Virol. 2005 Jun;79(12):7899-904. doi: 10.1128/JVI.79.12.7899-7904.2005.
Abstract
Epstein-Barr virus (EBV) is a human herpesvirus that causes infectious mononucleosis and is associated with several types of cancers, including nasopharyngeal carcinoma and Burkitt's lymphoma. An EBV protein that plays an integral role during lytic replication is the immediate-early protein BZLF1. Our laboratory has found that BZLF1 (Z) localizes to host chromosomes during mitosis. Two Z-interacting proteins are also found localized to mitotic chromosomes in the presence of Z. The association between Z and mitotic chromosomes may lead to the sequestering of Z-interacting proteins within the cell and potentially cause an alteration of chromosome compaction or chromatin structure.
摘要
爱泼斯坦-巴尔病毒（EBV）是一种人类疱疹病毒，可引起传染性单核细胞增多症，并与多种癌症相关，包括鼻咽癌和伯基特淋巴瘤。在裂解复制过程中起不可或缺作用的一种EBV蛋白是即刻早期蛋白BZLF1。我们实验室发现，BZLF1（Z）在有丝分裂期间定位于宿主染色体。在有Z存在的情况下，还发现两种与Z相互作用的蛋白也定位于有丝分裂染色体。Z与有丝分裂染色体之间的关联可能导致细胞内与Z相互作用的蛋白被隔离，并可能导致染色体压缩或染色质结构改变。
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