Chou Kee-Lee, Chi Iris
Sau Po Centre on Ageing, The University of Hong Kong, Hong Kong.
Int J Geriatr Psychiatry. 2005 Jun;20(6):570-5. doi: 10.1002/gps.1328.
To examine the association between diabetes and depression among older Chinese and to determine the extent to which depression is mediated by physical disability and diabetes-related comorbid conditions.
Cross-sectional analysis of data from a population-based study composed of a representative sample of 2003 non-institutionalized older adults aged 60 and older living in Hong Kong who agreed to participate in the study. We examined the relation between diabetes and depression (measured with the Geriatric Depression Scale).
12% of the older adults reported physician-diagnosed diabetes and amongst these older persons with diabetes, 26% of them reported elated level of depressive symptoms. Logistic regression analyses revealed that diabetes was significantly related to depression even when controlling for age, gender, marital status, and education. More importantly, adjusted for self-reported disability in three domains including self-care, mobility, and higher functioning did not attenuate this association but the association disappeared after we adjusted for four diabetes-related complications including heart disease, high blood pressure, stroke, and vision problems.
Diabetes is associated with depression and this association appears to be mediated by prevalent diabetes complications. This is of particular clinical important because although depression is often overlooked in the aged population, effective treatment is available and can result in improved medical outcomes.
研究中国老年人中糖尿病与抑郁症之间的关联,并确定身体残疾和糖尿病相关合并症对抑郁症的介导程度。
对一项基于人群的研究数据进行横断面分析,该研究样本为居住在香港的2003名60岁及以上同意参与研究的非机构化老年人的代表性样本。我们研究了糖尿病与抑郁症(用老年抑郁量表测量)之间的关系。
12%的老年人报告有医生诊断的糖尿病,在这些患有糖尿病的老年人中,26%报告有抑郁症状。逻辑回归分析显示,即使在控制了年龄、性别、婚姻状况和教育程度后,糖尿病与抑郁症仍显著相关。更重要的是,在对自我照顾、行动能力和更高功能这三个领域的自我报告残疾进行调整后,这种关联并未减弱,但在我们对包括心脏病、高血压、中风和视力问题在内的四种糖尿病相关并发症进行调整后,这种关联消失了。
糖尿病与抑郁症有关,这种关联似乎由常见的糖尿病并发症介导。这具有特别重要的临床意义,因为尽管抑郁症在老年人群中常常被忽视,但有效的治疗方法是可用的,并且可以改善医疗结果。