来自马鞍藤的胶原酶抑制性奎尼酸酯。

Collagenase inhibitory quinic acid esters from Ipomoea pes-caprae.

作者信息

Teramachi Fumihiro, Koyano Takashi, Kowithayakorn Thaworn, Hayashi Masahiko, Komiyama Kanki, Ishibashi Masami

机构信息

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

出版信息

J Nat Prod. 2005 May;68(5):794-6. doi: 10.1021/np0500631.

DOI:10.1021/np0500631

PMID:15921434

Abstract

Two new quinic acid esters (1 and 2) were isolated from the extract of Ipomoea pes-caprae together with six known quinic acid esters (3-8). The structures of compounds 1 and 2 were elucidated by spectroscopic data interpretation. These new compounds exhibited collagenase inhibitory activity and showed almost no cytotoxicity.

摘要

从马鞍藤提取物中分离出两种新的奎尼酸酯（1和2）以及六种已知的奎尼酸酯（3 - 8）。通过光谱数据分析阐明了化合物1和2的结构。这些新化合物表现出胶原酶抑制活性，并且几乎没有细胞毒性。