Zhao Yu, Zhao Jun, Li Xiang-ping, Zhou Chang-xin, Sun Han-dong, Hao Xiao-jiang, Xiao Pei-gen
College of Pharmaceutical Science, Zhejiang University, Hangzhou 310031, China.
Zhongguo Zhong Yao Za Zhi. 2006 Jun;31(11):869-74.
This paper reviewed updated research progresses of caffeoylquinic acids both in phytochemical and pharmacological aspects. The resources, distribution as well as the chemical structures of monocaffeoylquinic acids, dicaffeoylquinic acids, tricaffeoylquinic acids and multicaffeoylquinic acids are conclusively analyzed. The reviewed pharmacological investigations indicated that the caffeoylquinic acids exhibited significant activities such as anti-oxidation, anti-inflammation, enzyme inhibition, hypatoprotective and anti-PAF effects. The broad distribution and the remarkably pharmacological activities of these natural phenolic acids indicated their potential in the discovery and development of new natural drugs.
本文综述了咖啡酰奎宁酸在植物化学和药理学方面的最新研究进展。对单咖啡酰奎宁酸、二咖啡酰奎宁酸、三咖啡酰奎宁酸和多咖啡酰奎宁酸的资源、分布以及化学结构进行了总结分析。综述的药理学研究表明,咖啡酰奎宁酸具有显著的抗氧化、抗炎、酶抑制、保肝和抗血小板活化因子等活性。这些天然酚酸的广泛分布和显著的药理活性表明它们在发现和开发新型天然药物方面具有潜力。