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[用地高辛特异性抗体治疗夹竹桃自中毒]

[Nerium oleander self poisoning treated with digoxin-specific antibodies].

作者信息

Bourgeois B, Incagnoli P, Hanna J, Tirard V

机构信息

Samu de Grenoble, CHU de Grenoble, BP 207, 38043 Grenoble, France.

出版信息

Ann Fr Anesth Reanim. 2005 Jun;24(6):640-2. doi: 10.1016/j.annfar.2005.04.010.

Abstract

A chronically depressed 44-year-old man was rescued by the French medicalised ambulance service four hours after the ingestion of Nerium oleander leaves in a suicide attempt. Cardiotoxicity was evidenced by the presence of bradycardia with mental confusion and vomiting. The patient was empirically treated in the prehospital phase with a single dose of digoxin-specific Fab antibody fragments (Digidot). In spite of this treatment, the patient presented a new episode of important bradycardia (25 b/minute). Thereafter, the patient's rhythm stabilized and neurological signs and vomiting resolved. The patient recovered uneventfully and was discharged from the intensive care unit two days later.

摘要

一名44岁长期抑郁的男子在企图自杀吞食夹竹桃叶子四小时后,被法国医疗救护车服务部门救起。心动过缓伴精神错乱和呕吐证明存在心脏毒性。患者在院前阶段经验性地接受了单剂量地高辛特异性Fab抗体片段(Digidot)治疗。尽管进行了这种治疗,患者仍出现了一次严重心动过缓的新发作(每分钟25次)。此后,患者的心律稳定,神经症状和呕吐消失。患者康复顺利,两天后从重症监护病房出院。

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