大肠杆菌RecQ解旋酶：无胸腺嘧啶死亡中的一个参与者。
Escherichia coli RecQ helicase: a player in thymineless death.
作者信息
Nakayama Hiroaki
机构信息
Kyushu University (Emeritus), Fukuoka 812-8581, Japan.
出版信息
Mutat Res. 2005 Sep 4;577(1-2):228-36. doi: 10.1016/j.mrfmmm.2005.02.015.
DNA helicases of the RecQ family are distributed among most organisms and are thought to play important roles in various aspects of DNA metabolism. The founding member of the family, RecQ of Escherichia coli, was identified in a study aimed at clarifying the mechanism of thymineless death, a phenomenon underlying the mechanism for the cytotoxicity of the anticancer drug 5-fluorouracil. The present article is concerned solely with E. coli RecQ and tries to offer an integrated picture of the past and present of its study. Finally a brief discussion is given on how RecQ is involved in thymineless death.
RecQ 家族的 DNA 解旋酶分布于大多数生物体中，被认为在 DNA 代谢的各个方面发挥着重要作用。该家族的创始成员，即大肠杆菌的 RecQ，是在一项旨在阐明无胸腺死亡机制的研究中被鉴定出来的，无胸腺死亡是抗癌药物 5-氟尿嘧啶细胞毒性机制背后的一种现象。本文仅关注大肠杆菌 RecQ，并试图呈现其研究的过去和现在的综合图景。最后简要讨论了 RecQ 如何参与无胸腺死亡。
Zotero 插件