Thombs J, Borthwick N J, Hungerford J L, Cree I A
Ocular Oncology Service, Moorfields Eye Hospital, London, UK.
J Med Ethics. 2005 Jun;31(6):360-1. doi: 10.1136/jme.2004.009951.
The use of human tissue for scientific research is a highly sensitive issue. A lack of confidence in patient recruitment is one reason for the failure of many studies to be funded and it is important therefore that recruitment procedures are as effective and sympathetic as possible. The authors recruited patients with uveal melanoma into a postmortem study investigating tumour latency in this cancer. Two approaches were used--firstly a direct approach when patients attended clinic and secondly an initial approach by mail followed by telephone contact. In the first year of study the authors had a take up rate of 88.5%, significantly higher than the average rate of 40% quoted by the National Institute for Clinical Excellence (NICE). Key features are a sympathetic personal approach by experienced oncology nurses, the provision of clear information, and the inclusion of the next of kin in the recruitment procedure.
将人体组织用于科学研究是一个高度敏感的问题。对患者招募缺乏信心是许多研究未能获得资金的一个原因，因此，招募程序尽可能有效且人性化非常重要。作者招募了葡萄膜黑色素瘤患者参与一项死后研究，以调查该癌症中的肿瘤潜伏期。采用了两种方法——首先是患者到诊所时的直接方法，其次是先邮寄然后电话联系的初步方法。在研究的第一年，作者的接受率为88.5%，显著高于国家临床优化研究所（NICE）引用的40%的平均率。关键特征包括经验丰富的肿瘤学护士采用人性化的个人方法、提供清晰的信息以及在招募程序中纳入近亲。
