来自喀里多尼亚雨林林仙科植物的细胞毒性倍半萜类化合物。

Cytotoxic sesquiterpenoids from Winteraceae of Caledonian rainforest.

作者信息

Allouche Noureddine, Apel Cécile, Martin Marie-Thérèse, Dumontet Vincent, Guéritte Françoise, Litaudon Marc

机构信息

Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences de Sfax, B.P. 802, 3018 Sfax, Tunisia.

出版信息

Phytochemistry. 2009 Mar;70(4):546-53. doi: 10.1016/j.phytochem.2009.01.012. Epub 2009 Feb 27.

DOI:10.1016/j.phytochem.2009.01.012

PMID:19251287

Abstract

One secobutanolide, two butanolides and six drimane sesquiterpenoids were isolated from the bark and leaves of Zygogynum pancheri and Zygogynum acsmithii (Winteraceae) along with six known drimanes, isodrimanial, 1beta-O-p-methoxy-E-cinnamoyl-bemadienolide, 7-ketoisodrimenin, drimenin, polygodial and 1beta-E-cinnamoyl-6alpha-hydroxypolygodial. Their structures were elucidated through analysis of spectroscopic data. Drimane sesquiterpenoids with a dialdehyde function exhibited significant inhibitory activities in the in vitro cytotoxic assays against KB, HL60 and HCT116 cancer cell lines.

摘要

从潘氏合蕊五味子（Zygogynum pancheri）和阿斯密斯合蕊五味子（Zygogynum acsmithii）（林仙科）的树皮和叶子中分离出了一种异丁内酯、两种丁内酯和六种环戊烷并环庚烷倍半萜类化合物，以及六种已知的环戊烷并环庚烷类化合物，即异环戊烷并环庚烷、1β-O-对甲氧基-E-肉桂酰-贝马地诺内酯、7-氧代异环戊烷并环庚烷、环戊烷并环庚烷、聚伞花素和1β-E-肉桂酰-6α-羟基聚伞花素。通过光谱数据分析阐明了它们的结构。具有二醛功能的环戊烷并环庚烷倍半萜类化合物在针对KB、HL60和HCT116癌细胞系的体外细胞毒性试验中表现出显著的抑制活性。