Masineni Sreeharsha N, Chander Praveen N, Singh Gagan D, Powers C Andrew, Stier Charles T
Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA.
Am J Hypertens. 2005 Jun;18(6):878-84. doi: 10.1016/j.amjhyper.2004.12.014.
It is well-known that gender affects the progression of kidney failure. Male patients exhibit faster development of age-dependent renal disease than do women. In the present study, we examined arterial blood pressure (BP), proteinuria, and end-organ damage in male and female retired breeders from our colony of stroke-prone spontaneously hypertensive rats (SHRSP).
Male (n = 7) and female (n = 11) SHRSP littermates maintained on Purina Laboratory Chow 5008 and water were studied starting at 53 weeks of age. Systolic BP was measured by tail-cuff plethysmography and 24-h urinary protein excretion was quantified while animals were housed in metabolic cages. Blood was obtained by retro-orbital bleeding. Mean arterial pressure (MAP) was then monitored by radiotelemetry. Organs were preserved for histopathologic assessment.
Tail-cuff systolic BP did not differ between the sexes. Male SHRSP exhibited greater proteinuria (128 +/- 7 mg/d) than females (21 +/- 5 mg/d, P < .001). Blood urea nitrogen was higher in males (22 +/- 2 mg%) v females (15 +/- 1 mg%, P < .005). The MAP by radiotelemetry did not differ between the sexes (179 +/- 3 mm Hg in males v 192 +/- 6 mm Hg in females, 2 weeks after probe implantation). Stroke-related mortality was greater in males (83%) than females (10%). Renal vascular disease including thrombotic microangiopathy affecting glomeruli and microvessels and cardiac damage were more prominent in male SHRSP.
These findings demonstrate that male gender is a major risk factor for multisystem end-organ damage associated with aging and hypertension in SHRSP, despite comparable degrees of hypertension among males and females.
众所周知，性别会影响肾衰竭的进展。男性患者比女性患者表现出更快的年龄相关性肾病发展。在本研究中，我们检查了来自我们的易中风自发性高血压大鼠（SHRSP）群体的雄性和雌性退休繁殖者的动脉血压（BP）、蛋白尿和终末器官损伤。
从53周龄开始研究以普瑞纳实验室5008饲料和水饲养的雄性（n = 7）和雌性（n = 11）SHRSP同窝幼崽。通过尾袖体积描记法测量收缩压，并在动物置于代谢笼中时对24小时尿蛋白排泄进行定量。通过眶后放血获取血液。然后通过无线电遥测监测平均动脉压（MAP）。保存器官用于组织病理学评估。
尾袖收缩压在两性之间没有差异。雄性SHRSP的蛋白尿（128±7mg/d）比雌性（21±5mg/d，P <.001）更高。男性的血尿素氮（22±2mg%）高于女性（15±1mg%，P <.005）。无线电遥测的MAP在两性之间没有差异（植入探头后2周，雄性为179±3mmHg，雌性为192±6mmHg）。男性的中风相关死亡率（83%）高于女性（10%）。包括影响肾小球和微血管的血栓性微血管病以及心脏损伤在内的肾血管疾病在雄性SHRSP中更为突出。
这些发现表明，尽管雄性和雌性的高血压程度相当，但男性性别是与SHRSP衰老和高血压相关的多系统终末器官损伤的主要危险因素。
