Mostafa Badr E, Abdel Hay Hossam, Mohammed Hussam E, Yamani Mohammed
Departments of Otorhinolaryngology, Ain-Shams Universitiy, Cairo, Egypt.
ORL J Otorhinolaryngol Relat Spec. 2005;67(3):148-53. doi: 10.1159/000086016.
This was a prospective double blind comparative study on 40 patients. It compared the effects of the leukotriene receptor antagonist montelukast and beclomethasone nasal spray on the post-operative course of patients with sinonasal polyps. All patients underwent endoscopic sphenoethmoidectomy and were randomized post-operatively into two groups. Group I: 20 patients (9 females and 11 males) age 17 to 67 (32.4 +/- 9.5 years), receiving 10 mg montelukast orally daily and Group II: 20 patients (6 females and 14 males) age 17 years to 57 years (33.5 +/- 11.9 years), receiving 400 ug beclomethasone local sprays daily. All patients were followed up for 1 year and a symptom score was recorded throughout this period. There was a significant reduction in symptom scores in both groups throughout the study period. In the montelukast group improvement was more marked in itching, post-nasal discharge and headache. The control of sneezing and rhinorrhea was comparable in both groups with a marginal advantage of montelukast. Steroids had a more marked effect on smell disturbances and obstruction. There was no difference in the recurrence rate or in the need for rescue medications between both groups. Both drugs seem to have a complementary action and further studies are needed to determine which patients should receive which treatment.
这是一项针对40例患者的前瞻性双盲对照研究。该研究比较了白三烯受体拮抗剂孟鲁司特和倍氯米松鼻喷雾剂对鼻窦息肉患者术后病程的影响。所有患者均接受了鼻内镜蝶筛窦切除术，并在术后随机分为两组。第一组：20例患者（9例女性，11例男性），年龄17至67岁（32.4±9.5岁），每天口服10毫克孟鲁司特；第二组：20例患者（6例女性，14例男性），年龄17至57岁（33.5±11.9岁），每天接受400微克倍氯米松局部喷雾治疗。所有患者均随访1年，并在此期间记录症状评分。在整个研究期间，两组的症状评分均显著降低。在孟鲁司特组，瘙痒、鼻后滴漏和头痛的改善更为明显。两组在打喷嚏和流涕的控制方面相当，孟鲁司特略有优势。类固醇对嗅觉障碍和鼻塞的影响更为明显。两组之间的复发率或急救药物的需求没有差异。两种药物似乎具有互补作用，需要进一步研究以确定哪些患者应接受哪种治疗。
