10'-去甲氧基链黑菌素，链黑菌素的一种新型类似物。

10'-Desmethoxystreptonigrin, a novel analog of streptonigrin.

作者信息

Liu W C, Barbacid M, Bulgar M, Clark J M, Crosswell A R, Dean L, Doyle T W, Fernandes P B, Huang S, Manne V

机构信息

Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000.

出版信息

J Antibiot (Tokyo). 1992 Apr;45(4):454-7. doi: 10.7164/antibiotics.45.454.

DOI:10.7164/antibiotics.45.454

PMID:1592677

Abstract

10'-Desmethoxystreptonigrin, a novel analog of streptonigrin produced by Streptomyces albus, was discovered in a screen for inhibitors of farnesylation of RAS p21 protein. The compound was isolated from the fermentation broth and its structure determined. It is markedly cytotoxic to several human tumor cell lines and also exhibits potent broad-spectrum antibacterial activity.

摘要

10'-去甲氧基链黑菌素是由白色链霉菌产生的链黑菌素的一种新型类似物，它是在筛选RAS p21蛋白法尼基化抑制剂时发现的。该化合物从发酵液中分离出来并确定了其结构。它对几种人类肿瘤细胞系具有显著的细胞毒性，并且还表现出强大的广谱抗菌活性。