Shu Y Z, Huang S, Wang R R, Lam K S, Klohr S E, Volk K J, Pirnik D M, Wells J S, Fernandes P B, Patel P S
Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492.
J Antibiot (Tokyo). 1994 Mar;47(3):324-33. doi: 10.7164/antibiotics.47.324.
Three new manumycin class antibiotics, namely manumycins E, F and G, were isolated from the culture broth of Streptomyces sp. strain WB-8376. Their structures were established by spectroscopic methods, and the S configuration of C-4 in the epoxycyclohexenone moiety was determined by CD exciton chirality method for each of the three compounds. Manumycins E, F and G are active against Gram-positive bacteria, and have moderate inhibitory effects on the farnesylation of p21 ras protein. They demonstrated weak cytotoxic activity against human colon tumor cell HCT-116.
从链霉菌属菌株WB - 8376的培养液中分离出三种新的马尼霉素类抗生素，即马尼霉素E、F和G。通过光谱方法确定了它们的结构，并采用圆二色激子手性法确定了这三种化合物环氧环己烯酮部分中C - 4的S构型。马尼霉素E、F和G对革兰氏阳性菌有活性，对p21 ras蛋白的法尼基化有中等抑制作用。它们对人结肠肿瘤细胞HCT - 116表现出较弱的细胞毒性活性。
