Abe N, Nakakita Y, Nakamura T, Enoki N, Uchida H, Takeo S, Munekata M
Pharmaceutical Research Laboratories, Sapporo Breweries, Ltd., Shizuoka, Japan.
J Antibiot (Tokyo). 1993 Nov;46(11):1672-7. doi: 10.7164/antibiotics.46.1672.
In the course of our investigation aimed at the discovery of novel antitumor antibiotics from microorganisms, Streptomyces sp. G324 was found to produce the antitumor antibiotic, lavendamycin, and also, to yield the novel beta-carboline compounds, oxopropalines. We isolated five compounds as oxopropalines A, B, D, E and G. Oxopropalines B, D and G showed cytocidal activities against human or murine tumor cell lines in vitro.
在我们旨在从微生物中发现新型抗肿瘤抗生素的研究过程中，发现链霉菌属G324能产生抗肿瘤抗生素薰衣草霉素，还能产生新型β-咔啉化合物氧代丙啉。我们分离出了5种化合物，即氧代丙啉A、B、D、E和G。氧代丙啉B、D和G在体外对人或鼠肿瘤细胞系显示出杀细胞活性。
