阿维链霉菌 NEU1069 中四个具有杀螨和杀虫活性的新型道拉菌素同系物。
Four new doramectin congeners with acaricidal and insecticidal activity from Streptomyces avermitilis NEAU1069.
机构信息
School of Life Science, Northeast Agricultural University, Harbin, Heilongjiang, P R China.
出版信息
Chem Biodivers. 2011 Nov;8(11):2117-25. doi: 10.1002/cbdv.201000295.
Four new doramectin congeners, 1-4, were isolated from Streptomyces avermitilis NEAU1069. The structures of 1-4 were elucidated on the basis of spectroscopic analysis, including 1D- and 2D-NMR as well as HR-ESI-MS, ESI-MS, UV, and IR, and comparison with literature data. All compounds exhibited noticeable acaricidal and insecticidal activities. Especially compound 2 was found to be the most potent pesticide of the compounds evaluated with the IC(50) values of 10.2, 65.1 and 124.4 μg/ml against adult two-spotted spider mites (Tetranychus urticae Koch), two-spotted spider mite eggs, and Mythimna separata, respectively, which are comparable to those of commercial pesticide milbemycin A(3)/A(4) as positive reference.
从链霉菌 NEU1069 中分离到四个新的多拉菌素同系物 1-4。根据光谱分析，包括 1D 和 2D-NMR 以及 HR-ESI-MS、ESI-MS、UV 和 IR，以及与文献数据的比较，确定了 1-4 的结构。所有化合物均表现出显著的杀螨和杀虫活性。特别是化合物 2 是评估化合物中最有效的杀虫剂，对成体二斑叶螨（Tetranychus urticae Koch）、二斑叶螨卵和粘虫（Mythimna separata）的 IC（50）值分别为 10.2、65.1 和 124.4μg/ml，与商业杀虫剂米尔贝肟 A（3）/A（4）相当作为阳性对照。
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