Duckworth R M, Morgan S N, Gilbert R J
Unilever Dental Research, Port Sunlight Laboratory, Merseyside, United Kingdom.
J Dent Res. 1992 Apr;71 Spec No:836-40. doi: 10.1177/002203459207100S09.
The aims of this work were (a) to assess the oral bioavailability of fluoride delivered from dentifrices and (b) to test for a possible link between the results and clinical data obtained with the same dentifrices. Oral fluoride concentrations were measured in samples of saliva and plaque taken from seven subjects, after use of dentifrices which contained 0, 1000, 1500, and 2500 micrograms F/g as sodium monofluorophosphate. Salivary fluoride in samples obtained within the first few hours after a single dentifrice application, or up to 20 h after four weeks' daily use, increased with increasing F content of the dentifrice. For example, the mean zero-time intercepts of the second phase of salivary fluoride clearance curves for the above dentifrices were 0.46, 1.48, 1.88, and 3.03 mumol F/L, respectively. Plaque fluoride measured after four weeks' daily use of the dentifrices exhibited similar dose-response behavior. Linear regression analysis showed these trends to be statistically significant for both saliva (p less than 0.001) and plaque (p less than 0.025). Mean saliva and plaque fluoride concentrations were inversely associated with mean three-year caries increments for the three fluoride-containing dentifrices obtained in a recent clinical trial: DMFS scores 6.80, 6.33, and 5.71, respectively (Stephen et al., 1988). This suggests that oral fluoride measurements are a valuable in vivo method for the evaluation of the potential anti-caries efficacy of fluoride-containing dental products.
(a)评估牙膏中氟化物的口服生物利用度;(b)测试这些结果与使用相同牙膏获得的临床数据之间可能存在的联系。在7名受试者使用含0、1000、1500和2500μg F/g单氟磷酸钠的牙膏后,测量其唾液和牙菌斑样本中的口腔氟浓度。单次使用牙膏后最初几小时内或四周每日使用后长达20小时内采集的样本中的唾液氟,随牙膏中氟含量的增加而增加。例如,上述牙膏唾液氟清除曲线第二阶段的平均零时截距分别为0.46、1.48、1.88和3.03μmol F/L。每日使用牙膏四周后测量的牙菌斑氟表现出类似的剂量反应行为。线性回归分析表明,这些趋势在唾液(p<0.001)和牙菌斑(p<0.025)中均具有统计学意义。在最近一项临床试验中获得的三种含氟牙膏的平均唾液和牙菌斑氟浓度与平均三年龋齿增量呈负相关:DMFS评分分别为6.80、6.33和5.71(Stephen等人,1988年)。这表明,口腔氟测量是评估含氟牙科产品潜在防龋功效的一种有价值的体内方法。