Boxt L M, Katz J, Kolb T, Czegledy F P, Barst R J
Department of Radiology, College of Physicians and Surgeons, Columbia University, New York, New York.
J Am Coll Cardiol. 1992 Jun;19(7):1508-15. doi: 10.1016/0735-1097(92)90611-p.
To test the utility of electrocardiographically gated spin echo nuclear magnetic resonance (NMR) imaging in quantitating right and left ventricular volumes and function in patients with primary pulmonary hypertension, right and left ventricular end-diastolic and end-systolic volumes, stroke volumes and ejection fractions were determined in 11 patients with primary pulmonary hypertension and in 10 subjects with normal echocardiographic findings. Ventricular chamber volumes were computed by summing the ventricular chamber volumes of each NMR slice at end-diastole and end-systole. This technique was verified by comparison of results obtained by this method and with the water displacement volumes of eight water-filled latex balloons and ventricular casts of eight excised bovine hearts. In the patients with primary pulmonary hypertension, right ventricular volume indexes were 121 +/- 45 ml/m2 at end-diastole and 70.1 +/- 41.6 ml/m2 at end-systole; both values were significantly greater than values in the normal subjects (67.9 +/- 13.4 and 27.9 +/- 7.5 ml/m2, respectively). Left ventricular end-diastolic volume index was significantly less in the patients (44.9 +/- 9.7 ml/m2) than in the normal subjects (68.9 +/- 13.1 ml/m2). There was no significant difference in left ventricular end-systolic volume between the two groups (24.4 +/- 8.6 and 27.1 +/- 7.8 ml/m2, respectively). Right and left ventricular ejection fractions in the patients with primary pulmonary hypertension (0.43 +/- 0.21 and 0.46 +/- 0.15, respectively) were significantly less than values in normal subjects (0.59 +/- 0.09 and 0.6 +/- 0.11, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
为了测试心电图门控自旋回波核磁共振（NMR）成像在定量原发性肺动脉高压患者左右心室容积及功能方面的效用，我们测定了11例原发性肺动脉高压患者以及10例超声心动图检查结果正常的受试者的左右心室舒张末期和收缩末期容积、每搏量及射血分数。通过将每个NMR切片在舒张末期和收缩末期的心室腔容积相加来计算心室腔容积。通过比较该方法所得结果与八个充满水的乳胶气球的排水容积以及八个切除的牛心脏的心室铸型的结果，对该技术进行了验证。在原发性肺动脉高压患者中，右心室容积指数在舒张末期为121±45ml/m²，在收缩末期为70.1±41.6ml/m²；这两个值均显著高于正常受试者的值（分别为67.9±13.4和27.9±7.5ml/m²）。患者的左心室舒张末期容积指数（44.9±9.7ml/m²）显著低于正常受试者（68.9±13.1ml/m²）。两组之间左心室收缩末期容积无显著差异（分别为24.4±8.6和27.1±7.8ml/m²）。原发性肺动脉高压患者的左右心室射血分数（分别为0.43±0.21和0.46±0.15）显著低于正常受试者（分别为0.59±0.09和0.6±0.11）。（摘要截短于250字）
