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骨化性气管支气管病

Tracheopathia osteochondroplastica.

作者信息

Hussain Kashif, Gilbert Steven

机构信息

Department of Pulmonary-Critical Care, University of Wisconsin Hospital, Madison, Wisconsin 53791, USA.

出版信息

Clin Med Res. 2003 Jul;1(3):239-42. doi: 10.3121/cmr.1.3.239.

Abstract

The case of a male, 61 years of age, presenting with occasional hemoptysis and shortness of breath (duration of 1 year) is reported. Congestive heart failure was presumed and supported by chest x-ray and echocardiography. The patient improved with diuretic and angiotensin converting enzyme (ACE) inhibitor therapy, but continued to experience cough and occasional hemoptysis. Bronchoscopy revealed numerous firm nodular projections within the trachea with distribution along the cartilaginous rings. Tracheopathia osteochondroplastica (TPO) was diagnosed. TPO is an uncommon, benign, but slowly progressive disease of unknown etiology. It is characterized by endoluminal projection of cartilaginous and bony nodules arising in the submucosa of the trachea. Involvement may extend to lobar or segmental bronchi. TPO should be considered in cases where cough, dyspnea, persistent pulmonary infection, hoarseness, or recurrent hemoptysis remain after appropriate treatment of other presumptive underlying causes.

摘要

报告了一例61岁男性病例,该患者有偶尔咯血和气短症状(持续1年)。推测为充血性心力衰竭,胸部X光和超声心动图检查结果支持这一诊断。患者接受利尿剂和血管紧张素转换酶(ACE)抑制剂治疗后病情有所改善,但仍持续咳嗽并偶尔咯血。支气管镜检查发现气管内有许多坚实的结节状突起,沿软骨环分布。诊断为骨软骨瘤病性气管病(TPO)。TPO是一种病因不明的罕见、良性但进展缓慢的疾病。其特征是气管黏膜下出现软骨和骨结节的腔内突起。病变可能延伸至叶支气管或段支气管。在对其他推测的潜在病因进行适当治疗后,若仍存在咳嗽、呼吸困难、持续性肺部感染、声音嘶哑或反复咯血等情况,应考虑TPO。

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