Tajima K, Yamakawa M, Katagiri T, Sasaki H
Third Department of Internal Medicine, Yamagata University School of Medicine, Japan.
Virchows Arch. 1997 Nov;431(5):359-63. doi: 10.1007/s004280050111.
Tracheopathia osteochondroplastica (TO) is an unusual condition characterized by cartilaginous or bony submucosal nodules in the tracheobronchial tree. Bone morphogenetic protein-2 (BMP-2) and transforming growth factor beta-1 (TGF-beta 1) are potent inducers for new bone formation. We studied the precise localization of BMP-2 and TGF-beta 1 in two autopsied cases of TO, using immunohistochemical methods. Positive BMP-2 immunoreactivity was detected in numerous mesenchymal cells and chondroblasts lining the nodules in the tracheal submucosa. BMP-2 was not found in mature lamellar bony nodules. TGF-beta 1 was not seen in mesenchymal cells, though it did appear in chondrocytes and osteocytes in the nodules. These results suggest that BMP-2 plays an important role in nodule formation and acts synergistically with TGF-beta 1 to promote the nodules inductive cascade in the tracheal submucosa.
骨化性气管支气管病（TO）是一种罕见的疾病，其特征为气管支气管树内出现软骨性或骨性黏膜下结节。骨形态发生蛋白-2（BMP-2）和转化生长因子β-1（TGF-β1）是新骨形成的有效诱导剂。我们采用免疫组织化学方法，研究了两例TO尸检病例中BMP-2和TGF-β1的精确定位。在气管黏膜下层结节周围的众多间充质细胞和成软骨细胞中检测到BMP-2免疫反应阳性。在成熟的板层状骨结节中未发现BMP-2。虽然在间充质细胞中未见到TGF-β1，但在结节中的软骨细胞和骨细胞中出现了TGF-β1。这些结果表明，BMP-2在结节形成中起重要作用，并与TGF-β1协同作用，促进气管黏膜下层结节的诱导级联反应。
