Neumann A, Kasper D, Schultz-Coulon H J
Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, Plastische Operationen, Phoniatrie und Pädaudiologie, Städtische Kliniken Neuss, Lukaskrankenhaus GmbH.
HNO. 2001 Jan;49(1):41-7. doi: 10.1007/s001060050706.
Tracheopathia osteoplastica is a rare condition of the tracheobronchial tree characterized by the formation of multiple osseous or cartilaginous submucosal nodules which protrude into the lumen. Clinical features, pathological-anatomical, and radiological findings are described and discussed on the basis of three recent cases and a literature review.Two female patients (age 56 and 62 years) and one male (age 44 years) presented with recurrent tracheobronchitis, a "difficult intubation" at the time of an emergency situation requiring tracheostomy. The diagnosis was confirmed by tracheoscopy. CT scans showed radiodense nodular thickening of the tracheal wall compromising the lumen in all patients, whereas plain chest radiography revealed scalloped linear calcification in only one case. Histologically the nodules consisted of lamellar-type bone covered by normal mucosa. None of the patients needed therapeutic measures as there was no impairment of ventilatory function. The long-term observations (>15 years) of a few authors suggest that the disease is of benign course and does not deteriorate.
骨化性气管病是一种气管支气管树的罕见病症，其特征为形成多个突出至管腔内的骨性或软骨性黏膜下结节。基于最近的三例病例及文献综述，对其临床特征、病理解剖及影像学表现进行了描述和讨论。两名女性患者（年龄分别为56岁和62岁）及一名男性患者（年龄44岁）均表现为复发性气管支气管炎，在紧急情况下需要气管切开时出现“插管困难”。气管镜检查确诊了该病。CT扫描显示所有患者气管壁均有致密结节状增厚，管腔受累，而胸部X线平片仅在一例中显示出扇贝样线性钙化。组织学上，结节由正常黏膜覆盖的板层状骨组成。由于通气功能未受损，所有患者均无需治疗措施。少数作者的长期观察（>15年）表明，该病病程呈良性，不会恶化。
