Sugarbaker Paul H
Washington Cancer Institute, Washington Hospital Center, DC 20010, USA.
Curr Opin Oncol. 2005 Jul;17(4):397-9. doi: 10.1097/01.cco.0000161746.32511.41.
In the past, carcinomatosis from colorectal cancer was determined to be a lethal condition with a short survival.
A new treatment strategy starts with cytoreductive surgery in an attempt to remove all visible evidence of cancer implants. Then, chemotherapy is used in the operating room with moderate hyperthermia (41-43 degrees C) in an attempt to eradicate microscopic residual disease. Multiple phase II, a phase III, and a multi-institutional phase II study of 503 patients showed that approximately one-third of these patients can survive long term.
The expansion of treatment options, including cytoreductive surgery followed by chemotherapy with hyperthermia, to a larger number of patients is appropriate.
过去，结直肠癌所致癌性腹膜炎被认为是一种致死性疾病，生存期短。
一种新的治疗策略始于减瘤手术，试图清除所有可见的癌转移灶。然后，在手术室中进行化疗并适度热疗（41 - 43摄氏度），以试图根除微小残留病灶。多项II期、一项III期以及一项针对503例患者的多机构II期研究表明，这些患者中约三分之一能够长期存活。
将包括减瘤手术加温热化疗在内的治疗选择扩展至更多患者是合适的。
