Kumar Ashwani, Lajara-Nanson Walter A, Neilson Robert W
.Department of Internal Medicine, Resident Physician Texas Tech University Health Sciences Center, USA.
J Neurooncol. 2005 May;73(1):43-5. doi: 10.1007/s11060-004-2465-9.
A 69 year-old man developed sudden-onset multidirectional, constant, involuntary ocular movements associated with vertigo, truncal ataxia and involuntary movements of the lower limbs. These features were typical of opsoclonus-myoclonus-ataxia syndrome (OMS). MRI of the brain was normal. CSF studies showed a single oligoclonal IgG band. A chest x-ray showed a 2-centimeter lesion in the periphery of the left lung. Fine needle aspiration biopsy of this lesion revealed large B-cell lymphoma. OMS can be either idiopathic or a paraneoplastic manifestation of underlying malignancy. 20 of OMS cases are paraneoplastic in origin; breast and lung cancer are responsible for 70 of these. Association of this syndrome with non-Hodgkins lymphoma is rare, with only one case previously reported.
一名69岁男性突发多向性、持续性、不自主眼球运动，伴有眩晕、躯干共济失调及下肢不自主运动。这些特征是眼阵挛-肌阵挛-共济失调综合征（OMS）的典型表现。脑部MRI检查正常。脑脊液检查显示一条寡克隆IgG带。胸部X线显示左肺周边有一个2厘米的病灶。该病灶细针穿刺活检显示为大B细胞淋巴瘤。OMS可为特发性，也可为潜在恶性肿瘤的副肿瘤表现。20%的OMS病例起源于副肿瘤；其中70%由乳腺癌和肺癌引起。该综合征与非霍奇金淋巴瘤的关联罕见，此前仅报道过一例。
