Laroumagne S, Elharrar Xavier, Coiffard B, Plojoux J, Dutau H, Breen D, Astoul P
Department of Thoracic Oncology, Pleural Diseases, and Interventional Pulmonology, AP-HM-Hôpital Nord, Chemin des Bourrely, 13326 Marseille Cedex 20, France ; Aix-Marseille University, 13005 Marseille, France.
Department of Thoracic Oncology, Pleural Diseases, and Interventional Pulmonology, AP-HM-Hôpital Nord, Chemin des Bourrely, 13326 Marseille Cedex 20, France.
Case Rep Med. 2014;2014:545490. doi: 10.1155/2014/545490. Epub 2014 Mar 23.
Among paraneoplastic neurologic disorders (PND), opsoclonus-myoclonus syndrome, so-called "dancing eye syndrome," is a rare disorder combining multivectorial eye movements, involuntary multifocal myoclonus, and cerebellar ataxia. Although several paraneoplastic antibodies against postsynaptic or cell-surface antigens have been reported, usually most patients are serum antibody negative. We report a 65-year-old patient with opsoclonus-myoclonus syndrome revealing a small-cell lung carcinoma. If serologic antineuronal anti-body screening was negative, autoantibodies against glutamic acid decarboxylase (anti-GAD) were positive. Despite the specific anticancer treatment and high dose corticosteroids, the patient developed a severe and progressive encephalopathy and died 10 days later.
在副肿瘤性神经系统疾病（PND）中，眼阵挛-肌阵挛综合征，即所谓的“舞动眼综合征”，是一种罕见的疾病，其特征为多向量眼球运动、非自主性多灶性肌阵挛和小脑共济失调。尽管已经报道了几种针对突触后或细胞表面抗原的副肿瘤性抗体，但通常大多数患者血清抗体呈阴性。我们报告了一名65岁患有眼阵挛-肌阵挛综合征的患者，该患者被诊断出患有小细胞肺癌。如果血清学抗神经元抗体筛查为阴性，那么谷氨酸脱羧酶自身抗体（抗GAD）呈阳性。尽管进行了特异性抗癌治疗和大剂量皮质类固醇治疗，该患者仍发展为严重的进行性脑病，并于10天后死亡。
