Tasduq S A, Kaisar P, Gupta D K, Kapahi B K, Maheshwari H S, Jyotsna S, Johri R K
Division of Pharmacology, Regional Research Laboratory, Jammu-Tawi 180001 India.
Phytother Res. 2005 Mar;19(3):193-7. doi: 10.1002/ptr.1631.
The present report showed the hepatoprotective property of a 50% hydroalcoholic extract of the fruits of Emblica officinalis (fruit) (EO-50) against antituberculosis (anti-TB) drugs-induced hepatic injury. The biochemical manifestations of hepatotoxicity induced by rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA), either given alone or in combination were evaluated. In vitro studies were done on suspension cultures of rat hepatocytes while sub-acute studies were carried out in rats. The hepatoprotective activity of EO-50 was found to be due to its membrane stabilizing, antioxidative and CYP 2E1 inhibitory effects.
本报告显示了余甘子果实50%水醇提取物（EO-50）对抗结核药物诱导的肝损伤的保肝特性。评估了利福平（RIF）、异烟肼（INH）和吡嗪酰胺（PZA）单独或联合使用所诱导的肝毒性的生化表现。在大鼠肝细胞悬浮培养物上进行了体外研究，同时在大鼠身上进行了亚急性研究。发现EO-50的保肝活性归因于其膜稳定、抗氧化和CYP 2E1抑制作用。
