Li Qi, Li Hai-Jiao, Xu Tong, Du Huan, Huan Gang Chen-Lei, Fan Gang, Zhang Yi
College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
College of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Pharmacol. 2018 Jan 30;9:29. doi: 10.3389/fphar.2018.00029. eCollection 2018.
Liver disease is one of the most risk factors threatening human health. It is of great significance to find drugs that can treat liver diseases, especially for acute and chronic hepatitis, non-alcoholic fatty liver disease, and liver cancer. The search for drugs with good efficacy from traditional natural medicines has attracted more and more attention. Tibetan medicine, one of the China's traditional medical systems, has been widely used by the Tibetan people for the prevention and treatment of liver diseases for hundreds of years. The present paper summarized the natural Tibetan medicines that have been used in Tibetan traditional system of medicine to treat liver diseases by bibliographic investigation of 22 Tibetan medicine monographs and drug standards. One hundred and ninety three species including 181 plants, 7 animals, and 5 minerals were found to treat liver diseases in traditional Tibetan medicine system. The most frequently used species are , Brag-zhun, , and . Their names, families, medicinal parts, traditional uses, phytochemicals information, and pharmacological activities were described in detail. These natural medicines might be a valuable gift from the old Tibetan medicine to the world, and would be potential drug candidates for the treatment of liver diseases. Further studies are needed to prove their medicinal values in liver diseases treatment, identify bioactive compounds, elucidate the underlying mechanism of action, and clarify their side effects or toxicity with the help of modern phytochemical, pharmacological, metabonomics, and/or clinical trial methods.
肝脏疾病是威胁人类健康的主要风险因素之一。寻找能够治疗肝脏疾病的药物具有重要意义，尤其是对于急慢性肝炎、非酒精性脂肪性肝病和肝癌。从传统天然药物中寻找疗效良好的药物已越来越受到关注。藏医药作为中国传统医学体系之一，数百年来一直被藏族人民广泛用于预防和治疗肝脏疾病。本文通过对22部藏医药专著和药品标准进行文献调研，总结了藏医药传统体系中用于治疗肝脏疾病的天然藏药。在藏医药传统体系中，发现有193种药物可治疗肝脏疾病，其中包括181种植物、7种动物和5种矿物。最常用的品种有、榜准、、。详细描述了它们的名称、科属、药用部位、传统用途、植物化学信息和药理活性。这些天然药物可能是古老藏医药给予世界的一份珍贵礼物，有望成为治疗肝脏疾病的潜在候选药物。需要进一步研究以证明它们在治疗肝脏疾病方面的药用价值，鉴定生物活性化合物，阐明其潜在作用机制，并借助现代植物化学、药理学、代谢组学和/或临床试验方法阐明其副作用或毒性。
