白首乌块根粗提物及其各馏分的抗肿瘤活性

Antitumor activity of crude extract and fractions from root tuber of Cynanchum auriculatum Royle ex Wight.

作者信息

Shan Lei, Zhang Wei-Dong, Zhang Chuan, Liu Run-Hui, Su Juan, Zhou Yun

机构信息

School of Pharmacy, Second Military Medical University, Shanghai 200433, P. R. China.

出版信息

Phytother Res. 2005 Mar;19(3):259-61. doi: 10.1002/ptr.1678.

DOI:10.1002/ptr.1678

PMID:15934033

Abstract

Antitumor activity of the ethanol extract from the root tuber of Cynanchum auriculatum Royle ex Wight and four fractions of the ethanol extract were investigated, both in vitro and in vivo. The five samples exhibited cytotoxic activity on human tumor cell lines K562, SHG44, HCT-8, A549, PC3, in vitro and inhibition in mouse implanted sarcoma S180, in vivo. Among the five samples, fraction E was noted to be of the highest antitumor activity.

摘要

对耳叶牛皮消块根乙醇提取物及其四个部位进行了体内外抗肿瘤活性研究。这五个样品在体外对人肿瘤细胞系K562、SHG44、HCT-8、A549、PC3表现出细胞毒活性，在体内对小鼠移植性肉瘤S180有抑制作用。在这五个样品中，部位E的抗肿瘤活性最高。