Jain Tapan K, Morales Marco A, Sahoo Sanjeeb K, Leslie-Pelecky Diandra L, Labhasetwar Vinod
Department of Pharmaceutical Sciences, College of Pharmacy, Nebraska Medical Center, Omaha, Nebraska 68198-6025, USA.
Mol Pharm. 2005 May-Jun;2(3):194-205. doi: 10.1021/mp0500014.
We have developed a novel water-dispersible oleic acid (OA)-Pluronic-coated iron oxide magnetic nanoparticle formulation that can be loaded easily with high doses of water-insoluble anticancer agents. Drug partitions into the OA shell surrounding iron oxide nanoparticles, and the Pluronic that anchors at the OA-water interface confers aqueous dispersity to the formulation. Neither the formulation components nor the drug loading affected the magnetic properties of the core iron oxide nanoparticles. Sustained release of the incorporated drug is observed over 2 weeks under in vitro conditions. The nanoparticles further demonstrated sustained intracellular drug retention relative to drug in solution and a dose-dependent antiproliferative effect in breast and prostate cancer cell lines. This nanoparticle formulation can be used as a universal drug carrier system for systemic administration of water-insoluble drugs while simultaneously allowing magnetic targeting and/or imaging.
我们研发了一种新型的水分散性油酸（OA）-普朗尼克包覆的氧化铁磁性纳米颗粒制剂，它能够轻松负载高剂量的水不溶性抗癌药物。药物分配到围绕氧化铁纳米颗粒的OA壳层中，而锚定在OA-水界面的普朗尼克赋予制剂水分散性。制剂成分和药物负载均未影响核心氧化铁纳米颗粒的磁性。在体外条件下，观察到包封药物在2周内持续释放。相对于溶液中的药物，纳米颗粒在乳腺癌和前列腺癌细胞系中进一步表现出持续的细胞内药物保留以及剂量依赖性的抗增殖作用。这种纳米颗粒制剂可作为一种通用的药物载体系统，用于水不溶性药物的全身给药，同时实现磁性靶向和/或成像。
