大鼠肾脏中2,4-二氯苯氧乙酸（2,4-D）蓄积情况的研究。

Investigation of the accumulation of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat kidneys.

作者信息

Aydin Handan, Ozdemir Nurullah, Uzunören Nuray

机构信息

University Istanbul, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, 34310 Avcilar, Istanbul, Turkey.

出版信息

Forensic Sci Int. 2005 Oct 4;153(1):53-7. doi: 10.1016/j.forsciint.2005.04.018.

DOI:10.1016/j.forsciint.2005.04.018

PMID:15935583

Abstract

The accumulation of 2,4-dichlorophenoxyacetic acid (2,4-D) and its metabolite 2,4-dichlorophenol (2,4-DCP) in the kidneys of rats was investigated. Male and female Sprague-Dawley rats were given 2,4-D in drinking water and food for 30 days. Group A (control group) was fed a normal diet, Group B was fed 50 ppm 2,4-D in 15 g food, Group C received 100 ppm 2,4-D in 15 g food, Group D received 25 ppm 2,4-D in 15 ml drinking water and Group E was given 50 ppm 2,4-D in 15 ml of drinking water. Levels of 2,4-D and 2,4-DCP in kidneys were determined using high performance liquid chromatography (HPLC). It was observed that at low doses of 2,4-D, the metabolite, 2,4-DCP found in the kidneys.

摘要

研究了2,4-二氯苯氧乙酸（2,4-D）及其代谢物2,4-二氯苯酚（2,4-DCP）在大鼠肾脏中的蓄积情况。将雄性和雌性斯普拉格-道利大鼠在饮用水和食物中给予2,4-D，持续30天。A组（对照组）给予正常饮食，B组在15克食物中给予50 ppm的2,4-D，C组在15克食物中给予100 ppm的2,4-D，D组在15毫升饮用水中给予25 ppm的2,4-D，E组在15毫升饮用水中给予50 ppm的2,4-D。使用高效液相色谱法（HPLC）测定肾脏中2,4-D和2,4-DCP的水平。观察到在低剂量的2,4-D时，在肾脏中发现了代谢物2,4-DCP。