Aydin Handan, Ozdemir Nurullah, Uzunören Nuray
University Istanbul, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, 34310 Avcilar, Istanbul, Turkey.
Forensic Sci Int. 2005 Oct 4;153(1):53-7. doi: 10.1016/j.forsciint.2005.04.018.
The accumulation of 2,4-dichlorophenoxyacetic acid (2,4-D) and its metabolite 2,4-dichlorophenol (2,4-DCP) in the kidneys of rats was investigated. Male and female Sprague-Dawley rats were given 2,4-D in drinking water and food for 30 days. Group A (control group) was fed a normal diet, Group B was fed 50 ppm 2,4-D in 15 g food, Group C received 100 ppm 2,4-D in 15 g food, Group D received 25 ppm 2,4-D in 15 ml drinking water and Group E was given 50 ppm 2,4-D in 15 ml of drinking water. Levels of 2,4-D and 2,4-DCP in kidneys were determined using high performance liquid chromatography (HPLC). It was observed that at low doses of 2,4-D, the metabolite, 2,4-DCP found in the kidneys.
研究了2,4-二氯苯氧乙酸（2,4-D）及其代谢物2,4-二氯苯酚（2,4-DCP）在大鼠肾脏中的蓄积情况。将雄性和雌性斯普拉格-道利大鼠在饮用水和食物中给予2,4-D，持续30天。A组（对照组）给予正常饮食，B组在15克食物中给予50 ppm的2,4-D，C组在15克食物中给予100 ppm的2,4-D，D组在15毫升饮用水中给予25 ppm的2,4-D，E组在15毫升饮用水中给予50 ppm的2,4-D。使用高效液相色谱法（HPLC）测定肾脏中2,4-D和2,4-DCP的水平。观察到在低剂量的2,4-D时，在肾脏中发现了代谢物2,4-DCP。
