Stockinger Petra, Kvitsiani Duda, Rotkopf Shay, Tirián László, Dickson Barry J
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, A-1030 Vienna, Austria.
Cell. 2005 Jun 3;121(5):795-807. doi: 10.1016/j.cell.2005.04.026.
Male-specific fruitless (fru) products (Fru(M)) are both necessary and sufficient to "hardwire" the potential for male courtship behavior into the Drosophila nervous system. Fru(M) is expressed in approximately 2% of neurons in the male nervous system, but not in the female. We have targeted the insertion of GAL4 into the fru locus, allowing us to visualize and manipulate the Fru(M)-expressing neurons in the male as well as their counterparts in the female. We present evidence that these neurons are directly and specifically involved in male courtship behavior and that at least some of them are interconnected in a circuit. This circuit includes olfactory neurons required for the behavioral response to sex pheromones. Anatomical differences in this circuit that might account for the dramatic differences in male and female sexual behavior are not apparent.
雄性特异性无果（fru）产物（Fru(M)）对于将雄性求偶行为的潜力“硬连接”到果蝇神经系统中既必要又充分。Fru(M)在雄性神经系统中约2%的神经元中表达，但在雌性中不表达。我们已将GAL4插入fru基因座，这使我们能够可视化并操控雄性中表达Fru(M)的神经元以及雌性中的对应神经元。我们提供的证据表明，这些神经元直接且特异性地参与雄性求偶行为，并且其中至少一些在一个回路中相互连接。该回路包括对性信息素行为反应所需的嗅觉神经元。该回路中可能解释雄性和雌性性行为巨大差异的解剖学差异并不明显。
