用于生物防御的DNA疫苗。

DNA vaccines for biodefence.

作者信息

Garmory Helen S, Perkins Stuart D, Phillpotts Robert J, Titball Richard W

机构信息

Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, SP4 0JQ, UK.

出版信息

Adv Drug Deliv Rev. 2005 Jun 17;57(9):1343-61. doi: 10.1016/j.addr.2005.01.013. Epub 2005 Apr 13.

DOI:10.1016/j.addr.2005.01.013

PMID:15935877

Abstract

The advantages associated with DNA vaccines include the speed with which they may be constructed and produced at large-scale, the ability to produce a broad spectrum of immune responses, and the ability for delivery using non-invasive means. In addition, DNA vaccines may be manipulated to express multiple antigens and may be tailored for the induction of appropriate immune responses. These advantages make DNA vaccination a promising approach for the development of vaccines for biodefence. In this review, the potential of DNA vaccines for biodefence is discussed.

摘要

DNA疫苗的优势包括其构建和大规模生产的速度、产生广泛免疫反应的能力以及使用非侵入性手段进行递送的能力。此外，DNA疫苗可经操控以表达多种抗原，还可进行定制以诱导适当的免疫反应。这些优势使DNA疫苗接种成为生物防御疫苗开发的一种有前景的方法。在本综述中，将讨论DNA疫苗用于生物防御的潜力。